| Pathway Id | ko03410 |
| Class & Sub-Class | Class: Genetic Information Processing Sub-Class: Replication and repair |
| Description | Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions; derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway; thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates. Source: KEGG Database |
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